91小视频 I 天天射综合 I 蜜臀在线观看 I 亚洲美女一区 I 亚洲精品在线免费 I 日韩在线高清 I 一道本在线观看 I 国产女人毛片 I 欧美在线观看一区二区三区 I 成人综合激情网 I 最新日本中文字幕 I 黄色无毒网站 I 激情视频免费观看 I 伊人影视网 I 欧美日韩一级大片 I 在线观看日本网站 I 成人h动漫在线 I 亚洲国产成人精品激情在线 I 在线看日本 I 69xx网站 I 熟女俱乐部一区二区 I 一级人爱视频 I 国产精品网站免费 I 欧美毛片免费看 I 四虎av影视 I 日韩中出 I 久久日韩精品 I 久草热视频

Activity Measured by its ability to induce IL6
secretion by NHDF human normal dermal fibroblasts.
The ED50 for this effect is typically 26
ng/mL.
Measured by its ability to induce IL6
secretion by NIH-3T3 mouse embryonic fibroblast cells. Yao, Z. et al. （1995） Immunity 3:811.
The ED50 for this effect is typically 1.57.5
ng/mL.
Endotoxin Level <1.0 EU per 1 μg of the protein by the LAL method.
Purity >97%, by SDSPAGE
under reducing conditions and visualized by silver stain.
Formulation Lyophilized from a 0.2 μm filtered solution in HCl. See Certificate of Analysis for details.
PREPARATION AND STORAGE
Reconstitution Reconstitute at 100 μg/mL in 4 mM HCI.
Shipping The product is shipped with polar packs. Upon receipt, store it immediay at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freezethaw
cycles.
l 12 months from date of receipt, 20
to 70
°C as supplied.
l 1 month, 2 to 8 °C under sterile conditions after reconstitution.
l 3 months, 20
to 70
°C under sterile conditions after reconstitution.
BACKGROUND
Interleukin 17 （also known as CTLA8）
is a T cellexpressed
pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of
herpesvirus Saimiri. cDNA clones encoding IL17
have been isolated from activated rat, mouse and human T cells. Human IL17
cDNA encodes a 155 amino acid （aa）
residue precursor protein with a 19 amino acid residue signal peptide that is cleaved to yield the 136 aa residue mature IL17
containing one potential Nlinked
glycosylation site. Both recombinant and natural IL17
have been shown to exist as disulfidelinked
homodimers. At the amino acid level, human IL17
shows 72% and
63% sequence identity with herpesvirus and rat IL17,
respectively. An IL17
specific mouse cell surface receptor （IL17
R） has been cloned. While the expression of
IL17
mRNA is restricted to activated T cells, the expression of mIL17
R mRNA has been detected in virtually all cells and tissues tested. IL17
exhibits multiple
biological activities on a variety of cells including the induction of IL6
and IL8
production in fibroblasts, the enhancement of surface expression of ICAM1
in
fibroblasts, activation of NFκB
and costimulation of T cell proliferation. The nonglycosylated,
E. coliexpressed
rhIL17
has been shown to be active on human as
well as mouse cell lines.
References:
1. Yao, Z. et al. （1995） J. Immunol. 155:5483.
2. Yao, Z. et al. （1995） Immunity 3:811.
3. Rouvier, E. et al. （1993） J. Immunol. 150:5445

上海力敏實業有限公司代理R&D產品，咨詢 
上海力敏實業有限公司代理R&D產品，咨詢